Journal: Frontiers in Digital Health

Article Title: Guideline-based strategies to identify severe cytokine release syndrome in COVID-19 and cancer immunotherapy using large-scale electronic health records

doi: 10.3389/fdgth.2025.1625889

Figure Lengend Snippet: Definition of the cohorts of interests, inclusion and exclusion criteria. From the Optum® COVID-19 data, subjects with active COVID-19 or who received TCE treatment (blinatumomab) were isolated. The first COVID-19 infection or TCE treatment was considered a triggering event. Subjects with missing information on gender or age were excluded. Subjects with pre-existing comorbidities that share traits with CRS at least 7 days before the triggering event were excluded. A significant number of COVID-19 patients had no reported data 30 days around the triggering event and were excluded. Patients diagnosed with Sepsis within 30 days after onset were also excluded. Three cohorts of interest were used for subsequent CRS case identification: ‘COVID-19 adult cohort’, ‘TCE adult cohort’ and ‘TCE pediatric cohort’.

Article Snippet: Using the Optum® de-identified COVID-19 EHR dataset, we isolated 2.5 million patients with active COVID-19 and 171 individuals treated with the T-cell Engager (TCE) blinatumomab.

Techniques: Isolation, Infection

Journal: Frontiers in Digital Health

Article Title: Guideline-based strategies to identify severe cytokine release syndrome in COVID-19 and cancer immunotherapy using large-scale electronic health records

doi: 10.3389/fdgth.2025.1625889

Figure Lengend Snippet: Definition of the cohorts of interests, inclusion and exclusion criteria. From the Optum® COVID-19 data, subjects with active COVID-19 or who received TCE treatment (blinatumomab) were isolated. The first COVID-19 infection or TCE treatment was considered a triggering event. Subjects with missing information on gender or age were excluded. Subjects with pre-existing comorbidities that share traits with CRS at least 7 days before the triggering event were excluded. A significant number of COVID-19 patients had no reported data 30 days around the triggering event and were excluded. Patients diagnosed with Sepsis within 30 days after onset were also excluded. Three cohorts of interest were used for subsequent CRS case identification: ‘COVID-19 adult cohort’, ‘TCE adult cohort’ and ‘TCE pediatric cohort’.

Article Snippet: First, we do not know the origin of the TCE patients and we cannot exclude that this specific TCE cohort within the Optum COVID-19 data may derive from a study focusing on patients with specific comorbidities.

Techniques: Isolation, Infection